diff --git a/Include/slots.h b/Include/slots.h
index 4bf7bda0208a8d..3ef8768bbd26c3 100644
--- a/Include/slots.h
+++ b/Include/slots.h
@@ -42,7 +42,7 @@ struct PySlot {
 #define PySlot_STATIC_DATA(NAME, VALUE) \
     {.sl_id=(NAME), .sl_flags=PySlot_STATIC, .sl_ptr=(VALUE)}
 
-#define PySlot_END {0}
+#define PySlot_END {0, 0, {0}, {0}}
 
 
 // Macros without designated initializers (for C++11 and below):
diff --git a/Misc/NEWS.d/next/C_API/2026-10-05-17-09-35.gh-issue-149044.1HUiag.rst b/Misc/NEWS.d/next/C_API/2026-10-05-17-09-35.gh-issue-149044.1HUiag.rst
new file mode 100644
index 00000000000000..3861d23e27f8b3
--- /dev/null
+++ b/Misc/NEWS.d/next/C_API/2026-10-05-17-09-35.gh-issue-149044.1HUiag.rst
@@ -0,0 +1,2 @@
+Fix the :c:macro:`PySlot_END` macro for C++: initialize all members to avoid
+compiler warnings. Patch by Victor Stinner.